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Review on gymnema: an herbal medicine For diabetes management

Vaidya S

Diabetes has been recognized by western medicine since the early 1800 s as being one of the most prevalent and controllable conditions affecting a large portion ofthe population. Gymnema Sylvestre, an Ayurvedic herb, came to be known as "destroyer of sugar" because, in ancient times, Ayurvedic physicians observed that chewing a few leaves of Gymnema sylvestre suppressed the taste of sugar. It is used today all over India for controlling blood sugar. Several bioactives has been isolated from that herb for diabetes cure. The present review elaborate the bioactives and some facts and mechanism which make this herb an effective remedy for the same.

The therapeutic role of chelation in poison

Singhai A.K, Narayan Sailesh, Tayal Shivam, Diwan Ankit, Sahu Jagdish

Chelation refers to the coordination to the metal ion with a polydentate ligand. The complex so formed may results in precipitation of the metal or formation of stable, soluble compounds.Trace quantity of several metals are essentials constituents of the human body, because activity of many enzymes depends on these chelations. Though the amount of metal present is approx. 3% of body weight, but excess of any metal is harmful to body, its industrial and technological advances, metal pollution of the atmosphere has been increasing fast. Excess concentration of trace metal gradually accumulates in the body, leading to metal induced toxicity. Controlled removal of undesirable metal ions can be achieved by use of appropriate chelating agent.

Production of polyhydroxybutyrate From cafeteria waste : an environment Friendly approach

Srivastava Vivek Kumar1 and Shukla Ashish

The main objective of the study was the production of polyhydroxybutyrate (PHB) with the help of wastes as carbon sources to reduce the cost of production of PHB. This was accomplished by accessing the potential of PHB production from the waste samples taken from different industries. Four wild type strains named RBS1, RBS2, RBS3 & RBS4 were isolated from leather, textile, chrome, and molasses waste samples which are biochemically tested for PHB production. All four waste samples were tested for BOD measurement, COD measurement and TSS by adopting a novel repeated washing method. The BOD, COD and TSS of all four samples lied between 5 to 1450 mg/l, 23 to 3380 mg/l and 196 to 300 mg/l respectively for the cafeteria waste. The PHB concentration in leather sample was observed to be 3.970g/l. The PHB concentration in chrome sample was observed to be 0.461 g/l but the polymer was degraded with respect to time, hence, it was not appropriate for our objective. The PHB concentration in molasses was observed to be 3.953g/l.The maximum accumulation of PHB was in textile sample. Although accumulation of PHB in molasses was much uniform.

2D Qsar Study Of Quinazoline Derivatives As Potent Antimalarial Agents

Abha Shrivastava, A. B. Mundada, A. K. Pathak

Malaria is caused by a parasite called Plasmodium that is transmitted from one human to another by the bite of infected Anopheles mosquitoes. Plasmodium falciparum, the protozoan agent responsible for cerebral malaria, developed resistance to chloroquine. Quinazoline derivatives identified recently as potential antimalarial agents. New quinazoline derivatives displaying significant antiplasmodial properties, considering the possible affinity of such molecular scaffold for Plasmodium kinases which are parasitic targets of prime strategic importance for the future development of new antimalarial drug-compounds.
Quantitative structure activity relationship (QSAR) analysis was performed on a series of 4-anilinoquinazoline for their antimalarial activity by using VLife MDS software. Generated QSAR models were based on Partial Least Squares Regression coupled with Stepwise forward-backward method. QSAR study revealed that path cluster and element count are mainly responsible for antimalarial activity. The best 2 2 2 model showed r value = 0.9917, q value = 0.9415 and predicted r value = 0.9042. The results obtained from QSAR studies could be used in designing better antimalarial agents in future.

Validated Simultaneous Spectro Photometric Method For Estimation Of Paracetamol & Diclofenac Sodium In Tablet Dosage Forms Using Hydrotropic Solubilization Technique

Engla G ., Doshi A ., Soni. L.K. and Dixit V.K.

A novel, safe and sensitive method of spectrophotometric estimation in UV- region has been developed using 8M urea solution as hydrotropic solubilizing agent for the quantitative determination of DCS and PC. A poorly water soluble drugs in tablet dosage form. DCS have maximum max at 275.6 nm and obeys Beer's law in concentration range of 5-40 g/ml. PC have max at 243.4 nm and obeys beer's law in concentration range of 5-20 g/ml. Urea solution does not absorbs above 244 nm and does not show any interference in spectrophotometric estimation. Results of the analysis were validated statistically.

Formulation Development & Optimization Of Pioglitazone Hydrochloride Microspheres Using Ionotropic Gelation Technique

Abhishek Pandey, Vivek singh Bhadoria

The objective of the present study is to prepare sustained-release Pioglitazone Hydrochloride microspheres in different ratios by calcium chloride cross-linking method using iontropic gelation method. The prepared microspheres were subjected to various physicochemical evaluation and in vitro release studies. An attempt was made to prepare Microsphers of Pioglitazone by ionotropic gelation technique, with a view to deliver the drug at sustained or controlled manner in gastrointestinal tract and consequently into systemic circulation. The prepared Microsphers were evaluated for Compatibility study, Drug Entrapment Efficiency, In-vitro Dissolution, Scanning Electron Microscopy, DSC method. Among the six formulations prepared and evaluated F5 are found to show satisfactory results. The Prepared Microsphers shows entrapment efficiency of 69.62% to 91.25% and % yield value from 72% to 90%. Infrared spectroscopy confirmed the absence of any Drug-Polymer interaction. In-vitro release of Optimize batch (F5) was carried out in 7.4 pH phosphate buffer solution shows 92 % release up to 12 hour.